On-Chip Cytometry using Plasmonic Nanoparticle Enhanced Lensfree Holography

نویسندگان

  • Qingshan Wei
  • Euan McLeod
  • Hangfei Qi
  • Zhe Wan
  • Ren Sun
  • Aydogan Ozcan
چکیده

Computational microscopy tools, in particular lensfree on-chip imaging, provide a large field-of-view along with a long depth-of-field, which makes it feasible to rapidly analyze large volumes of specimen using a compact and light-weight on-chip imaging architecture. To bring molecular specificity to this high-throughput platform, here we demonstrate the use of plasmon-resonant metallic nanoparticles to automatically recognize different cell types based on their plasmon-enhanced lensfree holograms, detected and reconstructed over a large field-of-view of e.g., ~24 mm².

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عنوان ژورنال:

دوره 3  شماره 

صفحات  -

تاریخ انتشار 2013